Especially, two CD8 subsets (CD8+CD196-CD183-CD194+ and CD8+CD196+CD183-CD194+) seem to be crucial to distinguish T1D patients from healthy controls as well as T1D-group-A versus T1D-group-B, since they were ranked as the top-5 most relevant cell subsets selected by the EN-model (see Figures 2A, 3A). This evidence concerns the gene CCR4 and type 1 diabetes mellitus.