CD4 and type 1 diabetes mellitus: Consistent with previous reports showing that T cells are major drivers of T1D disease progression, the majority of immune cells selected by the model (Figure 2A and Supplementary Figure S3B) were CD4 and CD8 T cell subsets displaying distinct expression of CD25, CD45RA, CCR7/CD197 or CD27, and which in addition express one or multiple chemokine receptors (CXCR3/CD183, CCR4/CD194, CCR6/CD196).