Additionally, the NLRP3 inflammasome plays a critical role in Acinetobacter baumannii infection-induced pneumonia (85), Therefore, inhibiting the activation of the NLRP3 inflammasome has an effective therapeutic effect against inflammatory diseases caused by bacterial infections, which may be achieved by maintaining mitochondrial homeostasis through the suppression of pyroptosis (86). The gene discussed is NLRP3; the disease is bacterial infectious disease.