For instance, polyphyllin VI extracted from Trillium tschonoskii Maxim can induce caspase-1-mediated pyroptosis in NSCLC by inducing the ROS/NF-κB/NLRP3/GSDMD signaling axis, providing a possibility of becoming a novel therapeutic agent for NSCLC treatment in the future (19). This evidence concerns the gene NFKB1 and non-small cell lung carcinoma.