To confirm whether acrylamide-induced HF is driven by cardiac apoptosis, we showed that acrylamide significantly elevates the expression of Caspase 9 and Caspase 3, but not P53, Bax, and Bcl-2, in hearts (Fig. 3K), which was supported by previous zebrafish results. The gene discussed is CASP3; the disease is hydrops fetalis.