The KEGG analysis revealed that DEMs target genes were involved in signaling pathways including pathways of neurodegeneration, PI3K-Akt signaling, Alzheimer’s disease, MAPK signaling, Ras signaling, cAMP signaling, lipid and atherosclerosis, TNF signaling, ErbB signaling, and others (Figure S3). Here, TNF is linked to early-onset autosomal dominant Alzheimer disease.