RORA and posterior cortical atrophy: To investigate whether PPAT-EVs derived miRNAs, hsa-miR-106b-5p and hsa-miR-20a-5p, could regulate inflammation and proliferation in the 22Rv1 PCa cell line by targeting RORA gene, we silenced simultaneously and individually RORA gene expression and hsa-miR-106b-5p/hsa-miR-20a-5p correspondingly (Fig. 6).