RORA and posterior cortical atrophy: RORα1 variant has been demonstrated to have anti-proliferative activity, also affecting cell cycle progression in the DU145 androgen-dependent PCa cell line (by modulating p21 and cyclin A) as well as inhibiting the conversion of fatty acids into 5-5-Hydroxyeicosatetraenoic acid (responsible for the proliferative effect) [41].