For instance, pairs of iPSC lines differing only by the presence of a specific disease causing mutation have been generated for cystic fibrosis [34, 305, 306], primary ciliary dyskinesia [34, 307], alpha-1 antitrypsin deficiency [308, 309] and childhood interstitial lung disease [32, 43, 310]. The gene discussed is SERPINA1; the disease is hyperinsulinemic hypoglycemia, familial, 4.