CACNA1A and neoplasm: When the primary tumor volume reached 60–80 mm3, the tumor-bearing mice were randomly divided into 6 groups, including Control, Bi + mAb, Bi + mAb + RT, Bi + mAb + αPD-1, RT + αPD-1, and Bi + mAb + RT + αPD-1, as shown in Fig. 1A. As compared to both the control and Bi + mAb groups, the mice primary tumor growth in all the other treatment groups was inhibited; the Bi + mAb + RT therapy more effectively inhibited the tumor growth, and the addition of PD-1 inhibitor further enhanced the inhibitory effects.