As explored in this study, FOSL2 is upregulated in breast cancer and a high FOSL2 level is associated with breast cancer development, and the protein level of FOSL2 was also remarkably downregulated under ZN444B treatment in breast cancer cells and primary tumors from 4T1 breast cancer model (Figs. 4C-G and 5). The gene discussed is FOSL2; the disease is breast cancer.