Furthermore, EpCAM was previously shown to promote CRC cell invasion by EpICD-mediated activation of EMT-inducing genes, such as Snail1, Slug and Twist. In parallel, nuclear translocation of the EpICD-β-Catenin complex upregulates transcription of cell fate reprogramming genes, such as Oct4, Sox2 and c-Myc that confer self-renewal ability to CRC cells [4, 19]. Here, SOX2 is linked to colorectal carcinoma.