FZD5 and neoplasm: It is important to note that hEpAb2-6 also neutralizes EpEX activity, so the tumor-suppressive effects of the antibody observed in animal models are likely to be cumulative inhibitory effects on both EpEX- and EpICD-mediated mechanisms, not only the inhibition of EpICD-mediated Wnt receptor expression [5, 6, 8].