Histone Kla promotes the transcription of RUBCNL / Pacer, promotes autophagosome maturation by interacting with BECN1 (beclin 1), and mediates the recruitment and function of the class III phosphatidylinositol 3-kinase complex, which plays a crucial role in hypoxic cancer cell proliferation and survival [107]. This evidence concerns the gene BECN1 and cancer.