SPEN and Familial prostate cancer: For the prostate cancer GWAS, 5 out of the 382 (1.31%) genes prioritised by PascalX are known prostate cancer drivers (KLK2, KLK3, SPEN, TMPRSS2 and RNF43, Fisher exact p-value: 0.05, median distance to nearest index variant = 6.2 Kb).