For the non-cancer adipose-breast network that we applied to the breast cancer GWAS, Downstreamer prioritised seven known breast cancer driver genes among the top 100 genes: CREBBP, TRPS1, ARID1A, ARID1B, XBP1, SPEN and NUMA1 (Fig. 4). The gene discussed is ARID1A; the disease is breast carcinoma.