PUM1 and colonic neoplasm: This analysis also resulted in Bonferroni significant hits: in the matched non-cancer tissue-specific network analysis, we prioritised three genes for breast cancer, PHLPP1, PUM1 and CCL28 (p-values: 5.93 × 10− 7, 1.55 × 10− 6 and 2.01 × 10− 6, respectively), and two for colon cancer, ZZEF1 and BAZ2A (p-values: 1.94 × 10− 6 and 2.56 × 10− 6, respectively).