The case definition of AS-Hep-UA was refined to include age < 16 presenting no earlier than October 1st 2021 with an acute hepatitis and deranged serum liver enzymes (alanine transaminase (ALT) or aspartate transaminase (AST) > 500 IU/L) which could not be accounted for by other causes [7]. This evidence concerns the gene GPT and Acute hepatitis.