Furthermore, the MPD [49] suggested relevant phenotypes for genes where mutations in mice affect B cell number or differentiation (MCM3AP, RBM15 TRIB2, PICALM), or T cell number, differentiation and morphology (GC, DUSP10, PGAP3, SEPTIN9, BCL11B, DCK, SEPTIN9, PGAP3), decreased macrophage proliferation (NPFFR2), abnormal immune system physiology (NFATC2), mammary gland development (DGAT1), increased susceptibility to bacterial infection (HSF1), abnormal wound healing (PLEC), and abnormal mammary gland growth during pregnancy (TNFRSF11A). The gene discussed is PICALM; the disease is bacterial infectious disease.