DGKE and hemolytic-uremic syndrome: The International Hemolytic Uremic Syndrome group proposed the 2016 classification of HUS that included several disorders; shiga toxin-induced and pneumococcus-induced HUS, HUS associated with complement dysregulation or mutation of diacylglycerol kinase ε (DGKE), HUS related to cobalamin C defect, and HUS secondary to a heterogeneous group of causes (infections, drugs, cancer, and systemic diseases) [1].