METTL3 and neoplasm: In accordance with the clinical GC tissues, Liu et al. [16] detected that METTL3 expression was significantly increased in GC cell line and tumor tissues from The Cancer Genome Atlas (TCGA), Kaplan–Meier plotter, and Gene Expression Omnibus (GEO) database compared with control in big crowd data sets, and was related with more advanced tumor stage and grade in the survival analysis.