lncRNA NEAT1 (nuclear paraspeckle assembly transcript 1), acting as a scaffold mediated by ALKBH5, binds with EZH2 to promote the expression of downstream genes of EZH2 (a subunit of the polycomb repressive complex), which affects the malignant phenotype of GC such as invasion and metastasis progression [54]. The gene discussed is EZH2; the disease is gastric cancer.