Loss of YTHDF1 in GC tumors leads to recruitment of mature dendritic cells (DCs) with the increased expression of MHC II and the secretion of interleukin-12 (IL-12), which promoted CD4+ and CD8+ T cells infiltration as increased interferon-γ (IFN-γ) secretion in turn. The gene discussed is YTHDF1; the disease is gastric cancer.