Mechanistically, we elucidate how m6A modification facilitates the maturation and accumulation of miR-151-5p, a process orchestrated by METTL3 and a newly identified m6A reader, hnRNP U. This culminates in the accumulation of miR-151-5p, which, in turn, propels the malignant progression of HNSCC by targeting LYPD3 (Fig. 7). Here, METTL3 is linked to head and neck squamous cell carcinoma.