Among them, ephrin receptor EPHA4 (Gatto et al, 2014), actin binding LIM-proteins ABLIM1 and ABLIM2 (Barrientos et al, 2007), semaphorin SEMA7A (Korner et al, 2021) and glial neurotrophic factor GFRA2 (Wanigasekara et al, 2004) genes, which are involved in axon guidance, are commonly repressed in cancer cells by DiPRO1 and SIX1. The gene discussed is SIX1; the disease is cancer.