TRPC4 and Zika virus infectious disease: We found that HC-070, a potent TRPC4/5 inhibitor, significantly increased BHK cell survival (from 16.4 ± 0.9% to 88.3 ± 1.9%, P < 0.001) following ZIKV infection with an IC50 value of 4.5 ± 3.0 μM (n = 3).