Since ZIKV is quickly cleared in ZIKV-inoculated wild-type adult C57BL/6 mice, we used interferon receptor-deficient adult A129 mice (Ifnar−/− mice) and 1-day-old suckling ICR mice to detect whether ZIKV infection affects the TRPC4 level in the mouse brain. The gene discussed is IFNAR2; the disease is Zika virus infectious disease.