Minimal expression of Tau35 in transgenic mice induces key features of tauopathy, including deposition of highly phosphorylated and aggregated tau, progressive cognitive and motor deficits, autophagic/lysosomal dysfunction, including altered LC3-II and p62/SQSTM1 levels, and impaired synaptic plasticity [26, 27]. This evidence concerns the gene SQSTM1 and tauopathy.