Moreover, multiple studies have discovered a functional link between Hippo and RAS signaling: loss of Hippo activity switches RAS activation from promoting differentiation to aggressive proliferation contingent on nuclear YAP, oncogenic RAS can induce YAP activation, and YAP can compensate for the loss of activated KRAS in pancreatic ductal adenocarcinoma (PDAC) (Muzumdar et al, 2017; Kapoor et al, 2014; Yan et al, 2021). The gene discussed is KRAS; the disease is pancreatic ductal adenocarcinoma.