Similar perinuclear mitochondrial clustering was previously observed upon MIRO or Mfn1/2 overexpression, and with Charcot-Marie-Tooth syndrome Type 2A (CMT2A)-associated Mfn variants and disease-driving PARKIN mutants (Huo et al, 2022; Sloat and Hoppins, 2023; Huang et al, 2007; Lee et al, 2010). This evidence concerns the gene MFN1 and Charcot-Marie-Tooth disease type 2A1.