MAPT and frontotemporal dementia: One such example is the R723W mutation in the microtubule-associated protein tau (MAPT), associated with frontotemporal dementia/Parkinson’s disease, that creates a novel binding site (p + 1 position of the [ILPV]W-motif) for the kinase domain of the peripheral plasma membrane protein CASK (CASK) (no binding vs 39 μM; Fig. 4E; Table 1).