Finally, we highlight a talin 1 and 2 (TLN1 and TLN2) PTB binding site in the proto-oncogene tyrosine-protein kinase receptor Ret (RET), which is disrupted by two mutations (L1061P, Y1062A) linked to multiple endocrine neoplasia type 2 and to different types of tumours. Here, TLN1 is linked to multiple endocrine neoplasia type 2.