Many of the interaction perturbing mutations linked to neurological, metabolic and cardiovascular/haematological diseases are found in ion channels (calcium channel: CACNA1H; sodium channels: SCN1A, -5A, -9A and SCNN1B; potassium channel: KCND1, -J2; non-selective cation channel: TRPC6) and affect interactions with HECT type E3 ligases or with autophagy-related ATG8 proteins (Fig. 6B). Here, TRPC6 is linked to hematologic disorder.