At present, research on the function of ARC mainly focuses on cancer and heart diseases, and studies show that ARC plays an anti-apoptotic role by regulating the interaction between ARC and caspase or its receptor proteins, including the specific inhibition of caspase-2 and caspase-8 activity24,25, which can antagonize apoptosis caused by hypoxia and so on26. Here, CASP8 is linked to heart disorder.