PTPN11 and breast cancer: Likewise, the dependency on PTPN11 (SHP2) was noticeably more selective in TCGADEPMAP than DEPMAP (Fig. 2j,k), which was reflected by greater essentiality in a subset of patients with breast cancer (BRCA) (Extended Data Fig. 2e) that was absent from BRCA cell lines (Extended Data Fig. 2f).