EP300 and neoplasm: All told, this approach identified many known synthetic lethal pairs (for example, STAG1/STAG2, SMARCA2/SMARCA4 and EP300/CREBBP)41–43 and previously untested synthetic lethal candidates, demonstrating that TCGADEPMAP is well powered to predict synthetic lethal relationships with LOF events in patient tumor biopsies (Extended Data Fig. 3a–d and Supplementary Table 10).