Likewise, the dependency on PTPN11 (SHP2) was noticeably more selective in TCGADEPMAP than DEPMAP (Fig. 2j,k), which was reflected by greater essentiality in a subset of patients with breast cancer (BRCA) (Extended Data Fig. 2e) that was absent from BRCA cell lines (Extended Data Fig. 2f). This evidence concerns the gene PTPN11 and breast carcinoma.