After controlling for tumor lineage, PAPSS1 dependency in TCGADEPMAP was correlated with significantly worse OS (hazard ratio (HR) = 0.61, P = 0.0004) in patients with PAPSS2 deletion (Fig. 5f), demonstrating that PAPSS1 is a synthetic lethality target with potentially high translational impact. This evidence concerns the gene PAPSS2 and neoplasm.