KRAS and pancreatic ductal adenocarcinoma: PDXEDEPMAP also detected markedly stronger KRAS essentiality in KRAS-mutant PDX of pancreatic ductal carcinoma (PDAC) and colorectal carcinoma (CRC) lineages (Fig. 6c,d), whereas BRAF essentiality was strongest in BRAF-mutant PDX of cutaneous melanoma (CM) (Fig. 6e,f).