BRAF and rectum adenocarcinoma: For example, KRAS essentiality was markedly stronger in KRAS-mutant stomach adenocarcinoma (STAD), rectal adenocarcinoma (READ), pancreatic adenocarcinoma (PAAD) and colon adenocarcinoma (COAD) lineages (Fig. 2f,g), whereas BRAF essentiality was strongest in BRAF-mutant skin cutaneous melanoma (SKCM) (Fig. 2h,i).