NPPB and heart failure: The unadjusted regression coefficient for digoxin versus beta-blockers was 1.22 (95% CI −2.82 to 5.27; P = 0.55), and 0.66 when adjusted for age, gender, diagnosis of heart failure and N-terminal pro-hormone B-natriuretic peptide (NT-proBNP) (95% CI −3.45 to 4.77; P = 0.75).