According to KEGG, pathways enriched in the TLS+ group included the Autoimmune thyroid disease, Haematopoietic cell lines, The intestinal immune network promotes IgA production, primary immunodeficiency, and systemic lupus erythematosus, whereas pathways enriched in the TLS- group included ascorbate and aldehyde metabolism, cell cycle, drug metabolism other enzymes, neuroactive ligand-receptor interactions and pathways in cancer (Fig. 5a,b). The gene discussed is CD79A; the disease is inborn error of immunity.