Of the 15 cases performing WES, clinically relevant variants were identified in 5/15 (33.3%) cases, with diagnostic variants involving genes DNAH5, DNAH11, LRRC56, PEX10, and ZIC3; thus, the improved diagnostic yield of genetic causes via WES was 33.3%, the incremental diagnostic yield could facilitate the identification of accurate genetic variants that cause fetal dextrocardia, and was crucial for effective counseling, prognosis prediction, perinatal management of fetal dextrocardia, and recurrence risk prediction in the next pregnancy. Here, ZIC3 is linked to Dextrocardia.