MEIOB and spermatogenic failure: In Case 13, the fetus was affected by SIT and left ventricular hyperechoic foci; although no clinically related SNV/InDel was detected in the fetus, compound heterozygous likely pathogenic SNV, c.683-2A > G, and c.47delT (p.Leu16Argfs*8) in MEIOB, were detected in the mother and father, respectively, suggesting that they were carriers of ?spermatogenic failure 22 (OMIM 617706).