This finding was confirmed in the pancreatic cancer cell models, where only knockout of Zeb1, but not of Snail and Twist1 decreased ferroptosis sensitivity in TGFβ-treated KPCe cells (Extended Data Fig. 1g) and for cell lines generated from autochthonous tumours grown in mice with conditional knockout of Zeb1 versus Snail, as previously described15 (Extended Data Fig. 1h). Here, SNAI1 is linked to familial pancreatic carcinoma.