The same behaviour was observed for the pancreatic cancer cell line BxPC3 and sublines made resistant to the chemotherapeutic agent gemcitabine (Fig. 1f), as well as for MDA-MB-231 cells, where Zeb1 expression determines sensitivity to ferroptosis, but Zeb1-depleted cells, while highly resistant to ferroptosis, increase sensitivity to the chemotherapeutic agent etoposide (Extended Data Fig. 1e). This evidence concerns the gene ZEB1 and familial pancreatic carcinoma.