Concordant with a previous research33, we found that FLG (OR: 1.01, P = 1.79 × 10−6) was associated with atopic dermatitis (AD), and we also identified a novel gene-STAT5B with a more pronounced coefficient (1.16, P = 1.18 × 10−6). The gene discussed is STAT5B; the disease is atopic eczema.