Notably, FLG for AD (OR: 2.09, P = 6.54 × 10−53), ETV7 for Primary biliary cirrhosis (PBC, 1.98, P = 2.21 × 10−4), and ABCG2 for gout (1.69, P = 2.73 × 10−76) emerged with the most pronounced coefficients, while protective effects were also discerned for IL33-asthma (0.91, P = 4.12 × 10−25) and IFIH1-psoriasis (0.70, P = 1.81 × 10−8). This evidence concerns the gene FLG and primary biliary cholangitis.