PBRM1 and neoplasm: Given the co-occurrence of VHL and PBRM1 mutations (84%, 325/388 of PBRM1-positive tumours were also VHL mutated), after adjusting for VHL status, the association of PBRM1 mutational status was no longer statistically significant for either OS or CSS (HR = 0.68, 95% CI: 0.44–1.03; HR = 0.58, 95% CI = 0.33–1.02).