Moreover, genes involved in the maintenance of stem cell pluripotency, such as SOXC1 and SOXB1 expressed in the cyst stage of T. rubra, were substantially up-regulated during the reverse development of the ‘immortal’ jellyfish T. dohrnii19; the Wnt pathway and stem cell differentiation were also reported to be enriched in T. dohrnii cysts61. This evidence concerns the gene TBXT and cyst.