APLP1 and early-onset autosomal dominant Alzheimer disease: Furthermore, several genes associated with Alzheimer's disease (AD) exhibited multiple cells with an m/k = 1 ratio, including App, Apoe, Aplp1, Ctsb, and Itm2b (Fig. 6D; Supplemental Fig. S10; Supplemental Table S14; Turner et al. 2003; Priller et al. 2006; Hook et al. 2023), suggesting potential m6A regulation.