APLP1 and Alzheimer disease: Because an earlier study highlighted a decline in m6A levels with age and in AD (Castro-Hernández et al. 2023), our findings suggest that specific m6A transcripts like App, Apoe, Aplp1, Ctsb, and Itm2b, alongside m6A-modulated transcripts in CAMK2A neurons of the hippocampus, not only exhibit sensitivity to m6A regulation but are also likely implicated in the aging process and the pathology of AD.