Because an earlier study highlighted a decline in m6A levels with age and in AD (Castro-Hernández et al. 2023), our findings suggest that specific m6A transcripts like App, Apoe, Aplp1, Ctsb, and Itm2b, alongside m6A-modulated transcripts in CAMK2A neurons of the hippocampus, not only exhibit sensitivity to m6A regulation but are also likely implicated in the aging process and the pathology of AD. Here, CTSB is linked to Alzheimer disease.