c-KIT inhibition results in reduced pathology in TDP43 models of ALS (Spiller et al, 2018), whereas other studies found that a decrease in c-KIT expression in the spinal cord reduced survival of motor neurons compared with SOD1(G93A) mice, but the amount of motor neurons at end stage is similar (Staats et al, 2015). Here, SOD1 is linked to amyotrophic lateral sclerosis.