TKT and neurodegenerative disease: Collectively, these data suggest that multi-kinase inhibition provides an effective means of alleviating neurodegenerative pathologies (Hebron et al, 2013b, 2014; Mahul-Mellier et al, 2014; Lonskaya et al, 2015; Javidnia et al, 2017; Fowler et al, 2019), although future investigation into the effects of TK and other kinase inhibition may underlie synergistic and/or harmonious mechanisms (autophagy, anti-inflammation, etc.)to clarify how multi-target kinase inhibitors may function to promote therapeutic benefit in certain neurodegenerative diseases.