TARDBP and amyotrophic lateral sclerosis: c-KIT inhibition results in reduced pathology in TDP43 models of ALS (Spiller et al, 2018), whereas other studies found that a decrease in c-KIT expression in the spinal cord reduced survival of motor neurons compared with SOD1(G93A) mice, but the amount of motor neurons at end stage is similar (Staats et al, 2015).