In a metanalysis of 32 studies involving 10 491 COVID-19 patients, lymphopenia (3.33, p<0.00001), elevated CRP (OR 4.37, p<0.00001), D-dimer (3.39, p<0.00001) and PCT (6.33, p<0.00001) concentrations were independent markers of poor outcomes (Malik et al., 2021). This evidence concerns the gene CRP and COVID-19.