In this prospective evaluation of 16 EBV-markers and risk of NPC in Chinese adults from both NPC endemic and non-endemic regions, we demonstrated that, except for general infection marker VCAp18, IgA and IgG sero-positivity for the other 15 EBV antibodies were each significantly associated with higher risk of NPC. This evidence concerns the gene CD79A and nasopharyngeal carcinoma.