The 6-shogaol showed the favorable negative binding energies at -9.271 (BDNF) kcal/mol These findings also suggest that 6-shogaol may have a protective impact against 3-NPA-induced HD in the brain by improving behavioral activity, reducing oxidative stress, restoring neurotransmitters, inhibiting inflammatory markers, and downregulating NF-κB, BDNF, and Nrf2 expressions. The gene discussed is NFE2L2; the disease is Huntington disease.