GH1 and Mental deterioration: 33 Irregular mealtimes are associated with metabolic shifts, such aschanges in leptin or growth hormone–releasing peptide function, which in turn areassociated with impaired mental health.34 Additionally, food intake may modulate the gastrointestinal system,including the gut microbiota and enteroendocrine cells, which send signals to the centralnervous system via the gut-brain axis.5 Time-restricted eating, as 1 indicator of meal timing, plays a role inimproved neurogenesis and synaptic plasticity, thereby delaying cognitive decline andneurodegeneration.