Due to the fact that TCR only binds to MHC-antigen peptide complexes [42], therefore, in the crosstalk mechanism between COVID-19 and DLBCL, highly expressed SNCA may regulate MHC mediated protein antigen presentation through DCs, thereby activating the TCR signaling pathway, enhancing T cell-mediated anti-tumor immunity, and clearing DLBCL cells. Here, HLA-C is linked to COVID-19.