SLC23A2 and respiratory failure: Interestingly, phenotype analysis of SVCT2-deficient mouse offspring and placenta display starkly diminished or absent VC levels in blood and tissues, with prenatal supplementation in pregnant females failing to elevate blood VC concentrations in SVCT2-deficient pups, leading to perinatal lethality marked by respiratory failure and intraparenchymal brain hemorrhage [10, 11].