CXCR4 and B-cell chronic lymphocytic leukemia: Immunohistochemical staining confirmed these findings showing high GLUT1 (C) and low CXCR4 expression (D) in an osteolytic melanoma lesion (arrows; SUVmax 14.0 vs. 2.2) as opposed to intense CXCR4 expression (E) in a site with osseous CLL infiltration (dotted arrows; SUVmax 2.6 vs. 9.1).