Regarding Lox, Liu et al. [196] loaded Lox, syrosingopine, and Gd/CeO2 into ZIF-8 to develop urchin-like catalysts with a size of 300 nm via a wet-chemical approach, effectively depleting intratumoral lactate by releasing Lox (detected by hippocampal analyzer and lactate kit), achieving glycometabolic reprogramming to activate the M1 response in IL-4-induced BMDMs for achieving HCC-bearing mouse immunotherapy. This evidence concerns the gene IL4 and hepatocellular carcinoma.