In this study, we do not investigate downstream signaling of CDH3,however, in our other work, we did link CDH3 function to known downstreamregulators of migration in breast cancer animal models.57 Knocking down CDH3 in primary MMTV-PyMT tumororganoids inhibited laminin-332 and β-catenin associated signalingassociated with loss of phospho-FAK signaling.57 Thus, in our prior work, we establish that CDH3 regulatesdownstream signaling pathways associated with FAK signaling. The gene discussed is PTK2; the disease is breast carcinoma.