Others have demonstrated that EVs from cancer cells can also suppress T cells through adenosine signalling via A2AR, but in that case, exoplasmic adenosine seems to be generated by cancer EVs from extracellular ATP by the subsequent action of CD39, for the convesion of extracellular ATP or ADP to 5’‐AMP, and CD73 (5’‐nucleotidase) for the conversion of 5’‐AMP to adenosine (Morandi et al. 2018; Clayton et al. 2011; (Wang et al., 2021). Here, ADORA2A is linked to cancer.