The here reported immunomodulatory functions of spEVs thus have significant implications in various physiological and pathological processes, Understanding the role of spEVs in A2AR signalling in T‐cells may lead to innovative therapeutic approaches with regard to infertility and to increase the success rate of embryo transplantation after in vitro fertilization, but also in relation to prostate cancer. Here, ADORA2A is linked to Infertility.