CCL2 and familial pancreatic carcinoma: We found increased M1-like macrophage accumulation in estrogen-depleted mice, where elevated CXCL10 and CCL2 levels were observed, consistent with findings in a pancreatic cancer model where CXCL10/CXCR3 signaling was shown to maintain macrophages in the pro-inflammatory M1 phenotype (39).