ENTPD1 and neoplasm: Expression of Ezh2, important in Treg stability and function [12–14], and Entpd1 (gene encoding CD39), and percentage CD73+ of CD3+ cells, both critical enzymes involved in generation of immunosuppressive adenosine [15], were strongly downregulated confirming that a biologically/molecularly active drug concentration was achieved within the tumor and TME (Supplementary Figure 5C, 5D).