DC matured by co-culture with 1B3-transfected HCT116 induced production of the type 1 cytokines IFNγ and TNFα, and proliferation (expressed as percentage CTVlow cells) by CD4+, CD8+, and CD4-CD8- T cells whereas DC matured by mock or 3A1-transfected tumor cells had no or limited effect (Figure 6C–6G; Supplementary Figure 9E). Here, CD4 is linked to neoplasm.