We further investigated the potential role and clinical relevance of upregulated WTAP in the progression of inflammatory diseases, and revealed that both WTAP and IL6ST were upregulated in patients with SLE, asthma, sepsis, RA, psoriasis, and IBD (Supplemental Figure 1, A–F and Supplemental Figure 12, A–E). Here, IL6ST is linked to rheumatoid arthritis.