To reveal how m6A modification plays an essential role in inflammation and inflammatory diseases, we analyzed data obtained from the Gene Expression Omnibus (GEO) data sets (GSE13887/137268/69063/97779/166388/208303, Supplemental Table 1; supplemental material available online with this article; https://doi.org/10.1172/JCI177932DS1), and found that among m6A-related proteins, WTAP expression is commonly upregulated in patients with systemic lupus erythematosus (SLE), asthma, sepsis, rheumatoid arthritis (RA), psoriasis, or Crohn’s disease (Supplemental Figure 1, A–F). The gene discussed is WTAP; the disease is Sepsis.