Studies have reported that both STAT3 and HIF1-α can transcriptionally upregulate the expression of WTAP in some cancer cells (30, 31), but we found that LPS-induced upregulation of WTAP was not affected by SC144 treatment, which inhibited the activation of STAT3 signaling by binding to IL6ST (32) (Supplemental Figure 2, A and B). Here, STAT3 is linked to cancer.