NFKB1 and cancer: Because the STAT3 signaling axis has been well characterized as a mechanism that accelerates the production of a variety of cytokines and chemokines (62) and is strongly associated with inflammatory diseases, including cytokine storm syndromes, ADs, and cancers (63, 64), the NF-κB/WTAP/STAT3 axis identified in this study indicated that WTAP is an ideal therapeutic target for the treatment of many inflammatory diseases and cancers.