TNFRSF25 and obesity due to melanocortin 4 receptor deficiency: As for the genes involved in lipid metabolism, Pla2g2d, Lipo3, and Naaa were significantly upregulated, promoting anabolism, while lipid-transport-related genes, such as Abcg5, Apo3, and Stard5, were down-regulated, leading to lipid surplus and diverse metabolic syndromes, such as obesity.