It demonstrated that “hot” tumor group was enriched in the chemokine signaling pathway, cytokine-cytokine receptor signaling pathway, JAK-STAT signaling pathway, nature killer cell-mediated signaling pathway, B cell receptor, and T cell receptor signaling pathway in TCGA (Figure 5A), GSE76250 (Figure 5C), and GSE58812 datasets (Figure 5E). This evidence concerns the gene PPIB and neoplasm.