SIRPA and arthritic joint disease: Whilst SIRPα has been shown to suppress inflammation, the role of SIRPα in autoimmunity is somewhat mixed, as SIRPα promotes DC priming of autoreactive T cells in collagen-induced arthritis (192), experimental autoimmune encephalomyelitis (193), and nonobese diabetic mice (194); however, SIRPα agonism conversely suppresses monocyte and neutrophil infiltration in experimental arthritis and colitis (195).