In this context, pro-immunogenic mediators interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), and interleukin-2 (IL-2) have been shown to be upregulated in glioma surroundings after injection of miR-124 mimics, leading to a significant anti-glioma therapeutic impact (80). This evidence concerns the gene IFNG and central nervous system cancer.