CD274 and ovarian carcinoma: Disruption of PD-L1/PD-1 and CD80/CTLA-4 immune checkpoint signaling, as well as chemoresistance reversal mediated by miR-424 restoration, results in a synergistic effect that drives the escalating proliferation of specific CD8+T cells, causing an increase in the survival of a mouse model of ovarian cancer by decreasing myeloid-derived suppressive and regulatory T cells (78).