CD4 and multiple sclerosis: In the context of multiple sclerosis, Guerau-de-Arellano and colleagues demonstrated that overexpression of miR-128 and miR-27b in naive CD4(+) T cells, and miR-340 in memory CD4(+) T cells, leads to the suppression of BMI1 and IL4, reduction in GATA3 levels, and a cytokine shift from Th2 to Th1 phenotype.