HIF-α promotes tumor progression by regulating the expression of key target genes (16), as HIF-1α supports tumor angiogenesis by enhancing the expression of vascular endothelial growth factor (VEGF) (17), and it also facilitates glucose uptake and glycolysis by upregulating the expression of glucose transporter 1 (GLUT1) and related genes (18). The gene discussed is SLC2A1; the disease is neoplasm.