Similarly, we found that some important signaling pathways related to tumor progression, including PPAR signaling pathway, Hedgehog (Hh) signaling pathway, Calcium (Ca2+) signaling pathway, GnRH signaling pathway, ErbB signaling pathway, and Wnt signaling pathway, were enriched in PHD2-deficient H1299 cell (Figure 7B). Here, GNRH1 is linked to neoplasm.