Moreover, in this study, KEGG analysis revealed that some important signaling pathways related to tumor progression, including PPAR signaling pathway, Hh signaling pathway, Ca2+ signaling pathway, GnRH signaling pathway, ErbB signaling pathway, and Wnt signaling pathway, were enriched in PHD2-deficient H1299 cell. The gene discussed is GNRH1; the disease is neoplasm.