NFKB1 and neoplasm: Furthermore, we found that some important signaling pathways related to tumor progression, including NF-kappaB (NF-κB) signaling pathway, Notch signaling pathway, Wnt signaling pathway, and phosphatidylinositol 3-kinase (PI3K) signaling pathway, were enriched in PHD2-deficient H1299 cells (Figure 6B).